Roles for SUMO in pre-mRNA processing
نویسندگان
چکیده
منابع مشابه
Distinct roles of Pcf11 zinc-binding domains in pre-mRNA 3′-end processing
New transcripts generated by RNA polymerase II (RNAPII) are generally processed in order to form mature mRNAs. Two key processing steps include a precise cleavage within the 3' end of the pre-mRNA, and the subsequent polymerization of adenosines to produce the poly(A) tail. In yeast, these two functions are performed by a large multi-subunit complex that includes the Cleavage Factor IA (CF IA)....
متن کاملRoles of SUMO in Plants
The covalent conjugation of SUMO (Small Ubiquitin-related MOdifier) protein to its substrates regulates numerous cellular processes, including protein stability and activity in eukaryotes as well as in plants. In this present review, we summarize biochemical aspects of SUMO conjugation and deconjugation and the functions of SUMO and sumoylation-related proteins in Arabidopsis and other plants. ...
متن کاملPre-mRNA processing: Insights from nonsense
In eukaryotic cells, translation is thought to be confined to cytoplasm, but two recent studies have challenged this notion, one showing that an mRNA's open reading frame influences nuclear events as early as release from the site of transcription, and the other by providing evidence for protein synthesis within the nucleus.
متن کاملCoordination between transcription and pre-mRNA processing.
A large body of work has proved that transcription by RNA polymerase II and pre-mRNA processing are coordinated events within the cell nucleus. Capping, splicing and polyadenylation occur while transcription proceeds, suggesting that RNA polymerase II plays a role in the regulation of these events. The presence and degree of phosphorylation of the carboxy-terminal domain of RNA polymerase II la...
متن کاملRegulation of pre-mRNA processing by src
BACKGROUND Changes in gene expression in response to external signals provide a key mechanisms for the regulation of higher eukaryotic cell functions. The importance of transcriptional control in the response of cells to growth factors and cytokines has been extensively documented, but gene expression has also been shown to be controlled at other levels, such as the stability of mRNA in the cyt...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Wiley Interdisciplinary Reviews: RNA
سال: 2015
ISSN: 1757-7004
DOI: 10.1002/wrna.1318